Teenage pregnancy is a public health concern both in developed and developing world. In Ghana especially, in the northern part of the country where illiteracy rates are high with majority of the people been poor and child marriage is a common phenomenon.  In the West Mamprusi District, pregnancy among adolescent girls has reached pandemic heights. Despite several interventions by both government and Non- Governmental organizations, the problem still persists. This study therefore investigates the major predictors of teenage pregnancy in the area. Using a stratified random sampling technique, a total of 196 respondents were selected for the study. The main tools used for the study were individual interview guides and questionnaires. The results indicate that peer group influence,  poverty, lack of parental control,  inadequate sex education as well as the role played by both  mass and social media are the main predictors of teenage pregnancy in the area. The study therefore recommended that birth control measures should be put in place to curtain the number of teenage pregnancies in the area. Also stake holders in the area should embrace formal education especially the girl child. Initiation and sustaining empowerment programmes for drop outs in the area should be encouraged.